A Novel Synthesis of Benzo(c)phenanthridine Skeleton and Biological Evaluation of Isoquinoline Derivatives.
نویسندگان
چکیده
منابع مشابه
A novel synthesis of benzo[c]phenanthridine skeleton and biological evaluation of isoquinoline derivatives.
Benzo[c]phenanthridine skeleton was synthesized from easily available starting N-methyl-o-toluamide 2 and o-methylbenzonitrile 5 in 7 steps. Radical cyclization of styrene 10 afforded 6,11-dimethyl-6,11-dihydro-5H-indeno[1,2-c]isoquinolin-5-one 13. Most 3-arylisoquinolines have displayed strong activities against human tumor cell lines. Especially, indenoisoquinolinone 13 exhibited excellent cy...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1999
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.47.900